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Development of a technology for obtaining the Momordica charantia L. aqueous extract

Abstract:

Introduction: Momordica charantia L. aqueous extracts have scientificallyconfirmed therapeutical potential, which makes it possible to use it in the treatment of several diseases, particulary diabetes. Obtaining a standardized extract is of great importance to reproduce it at industrial scale and also to obtain a pharmaceutically active ingbkp_redient (FAI) for the development of orally administered finished forms. Objectives: to develop a technology at lab scale to obtain standardized aqueous extract from Momordica charantia L. Methods: the study of the operational parameters (vegetal matter-solvent ration and extraction time) was performed in a lab reactor designed according to the dimensions of an industrial reactor, with a 3-level surface design of factorial response (3^2). Results: the studied factors significantly influence the extraction process in which time is the most influential. There exists direct proportion between vegetal mattersolvent ration and the content of extracted solids, being the latter inversely proportionate to the extraction time. The highest content of extracted solids was reached with vegetal matter-solvent ratio of 1:25 and extraction time of 0.5 hours. Conclusions: the operational conditions that support the highest solid extraction in obtaining the aqueous extract at the experimental phase were determined when the vegetal matter-solvent ratio and the extraction time were 1:25 and 0.5 hours respectively.