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Development of dendrimer-based nanomaterials for diagnostic and therapeutic applications

Abstract:

Dendrimer-based nanomaterials are a promising generation of nanoagents for diagnostic and therapeutic applications. The present chapter initially describes dendrimers history, architectures, synthesis strategies, and main types. Then the physicochemical characteristics of dendrimers are discussed in detail. Numerous designs and applications of dendrimer-based nanomaterials in biological systems are then reviewed. This chapter focuses on their applications on drug or gene delivery devices. Besides, biocompatibility of dendrimer- based nanomaterials is also highlighted, such as in vitro and in vivo toxicity, as well as immunogenicity and biopermeability.