Diethylphosphoryl-oxymab (DEPO-B) as a solid coupling reagent for amide bond formation

Abstract:

A new phosphonium based coupling reagent DEPO-B has been synthesized from 5-(hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophos-phate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.

Año de publicación:

2019

Keywords:

• coupling reagent
• SOLUBILITY
• Hydrolytic stability
• Diethylphosphoryl-OxymaB
• Phosphonium salts

Fuente:

scopus