Directed module detection in a large-scale expression compendium

Abstract:

Public online microarray databases contain tremendous amounts of expression data. Mining these data sources can provide a wealth of information on the underlying transcriptional networks. In this chapter, we illustrate how the web services COLOMBOS and DISTILLER can be used to identify condition-dependent coexpression modules by exploring compendia of public expression data. COLOMBOS is designed for user-specified query-driven analysis, whereas DISTILLER generates a global regulatory network overview. The user is guided through both web services by means of a case study in which condition-dependent coexpression modules comprising a gene of interest (i.e., "directed") are identified. © 2012 Springer Science+Business Media, LLC.

Año de publicación:

2012

Keywords:

• Motif
• Expression profile
• Condition annotation
• transcriptomics
• Microarray compendium
• Bi-cluster
• Coexpression module
• web service
• Regulatory network

Fuente:

scopus

google