Acute topical toxicity and dermal irritability of decoction of Piper auritum Kunth (caisimón de anís)

Abstract:

Introduction: Piper auritum Kunth, commonly known as caisimón de anís or anisón in some regions of the country, is a plant widely used as topical antiinflammatory. To this end, leaves may be warmed up and applied to the damaged area or a decoction prepared and drunk. Objective: determine the acute topical toxicity and primary dermal irritability of a 50% decoction of Piper auritum fresh leaves. Methods: fresh leaves collected on the same day of the assay were used to prepare a decoction, following the techniques described in Guideline 434 of the Organization for Economic Co-operation and Development (OECD 434) about dermal toxicity in Wistar rats. Decoction was kept in contact with previously shaved skin for 24 hours. The weight of animals was controlled before, during and upon completion of the experiment. OECD Guideline 404 was used for topical irritability in New Zealand rabbits, applying the extract to a previously shaved area for 4 hours. Results: no sign or symptom of toxicity due to dermal absorption was observed in the rats. Rabbits did not show any evidence of edema or erythema. Conclusions: Piper auritum Kunth 50% decoction has a low irritability and dermal toxicity rate in our test conditions.

Año de publicación:

2014

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Fuente:

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