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Disulfide-Based Protecting Groups for the Cysteine Side Chain

Abstract:

Two new disulfide-based protecting groups (SIT and MOT) are proposed for Cys thiol in the substitution of StBu, which is often difficult to remove. Both groups are based on a secondary thiol with a branched point in the β-position for an efficient modulation of its lability and/or stability. This unique structure allows them to be fully compatible with Fmoc/tBu SPPS. At the end of the synthesis, these groups are removed in a straightforward manner with dithiothreitol with some H2O.

Año de publicación:

2020

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Química orgánica
    • Bioquímica

    Áreas temáticas:

    • Química orgánica

    Contribuidores:

    Chakraborty A.Chakraborty A.
    Alberício F.Alberício F.
    Sharma A.Sharma A.
    B. G. De la TorreB. G. De la Torre