Does increased FIO<inf>2</inf> alter NADH redox state and protect brain cells from ICP changes in rabbits?

Abstract:

Elevated intracranial pressure (ICP) is an important pathophysiologic feature of head injury, post-ischaemic reperfusion, and a variety of disease states including cerebral oedema, infection and haemorrhage. Reduced blood flow to the brain and brain stem and imbalance between oxygen supply and demand are viewed as key mechanisms of injury from elevated ICP. Despite the importance of these mechanisms, there is little information on the relationship of intracranial pressure to brain oxygenation. Therefore, we designed this study to examine the effect of progressive changes in ICP on cerebrocortical oxygenation and cerebral blood volume, and also to determine if increased inspired oxygen concentration protects brain cells against these intracranial pressure changes.

Año de publicación:

1988

Keywords:

Fuente:

scopus