Advanced cell therapy for the treatment of osteochondral defects: from product devel-opment to the clinical trial

Abstract:

Background: As currently available literature shows, mesenchymal stem cells (MSC) represent an immense potential in clinical applications. Their immunomodulatory properties and their differentiation capacity at least into osteoblasts, chondroblasts and adipocytes, make many diseases a scope of application. Collection from bone marrow, the most commonly used source of MSC, represents an extremely invasive and painful collection procedure. Therefore, human umbilical cords (hUC) would be a perfect substitute. For cultivation fetal calf serum (FCS) is preferred until now, despite ethical concerns and the risk of disease transmission. Since also human serum (huS) and human platelet lysate (hPL) could be used as media supplements for MSC, a comparison was performed. Methods: hUC obtained after caesarian sections were used. For cell retrieval explant cultures were carried out: the cords were minced and …

Año de publicación:

2013

Keywords:

Fuente:

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