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EVALUATION OF THE LIPOPHIUC EXTRACT OF Cucurbita pepo L. ON THE BENIGN PROSTATIC HYPERPLASIA.

Abstract:

正 We studied the effect of the lipophilic extract of seeds of Cucurbita pepo L.(ELMSC) in the pattern in vitro of the deferential conduit of rats and in the benign prostatic hyperplasia induced by testosterone propionate during 15 days. An increase of the concentration half inhibitoria of norepinefrina was observed (7.5× 10-7 at 2× 10-5) of the deferential conduit in presence of 1mg/mL of the ELMSC in the bathroom of isolated organ; to the doses of 400 and 200 mg/kg the extract caused a significant decrease of the growth prostatic. Our data indicate that the ELMSC to dose bigger than 200 mg/Kg inhibits the growth prostatic induced by the testosterone in the experimental pattern of prostatic hyperplasia in rats and it presents activity antagonistic alpha adrenergic in the pattern of isolated organ of deferential conduit of rat to the concentrations of 1 and 3 mg/mL.