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EXCESS RISK OF PRETERM DELIVERY WITH PERICONCEPTIONAL IRON SUPPLEMENTATION IN A MALARIA ENDEMIC AREA

Abstract:

Introduction: Iron supplementation before the first pregnancy may improve future maternal and infant health by reducing maternal anemia. Objective: to assess the risk of preterm delivery with periconceptional iron supplementation in a malaria endemic area. Methods: A double-blind randomized controlled trial. Nulliparous, mainly adolescent females, were individually randomized periconceptionally Results: 478 pregnancies occurred to 1959 women: 258/980 women assigned iron and folic acid and 220/979 women assigned folic acid alone. Conclusions: Long-term weekly iron supplementation of nulliparous women in a malaria-endemic area was associated with an increased risk of preterm delivery in their first pregnancy.