Adverse drug reaction driven immunosuppressive drug manipulations: a single‐center comparison of enteric‐coated mycophenolate sodium vs. mycophenolate mofetil

Abstract:

Abstract:  Enteric‐coated mycophenolate sodium (MPS) has been developed to help circumvent the upper gastrointestinal side‐effects of mycophenolic acid by facilitating drug release in the small intestine. Many questions regarding the side‐effect profile of MPS remain. Therefore, the purpose of this study is to review a single‐center’s experience with mycophenolate mofetil (MMF) and MPS. Methods:  This retrospective, sequential cohort analysis of de novo renal and pancreas transplants (n = 198) compared MMF 500 mg b.i.d. to MPS 360 mg b.i.d. in conjunction with antibody induction, tacrolimus, and steroids. Results:  There were fewer adverse event driven drug manipulations in the MPS group at 90 d (4% MPS vs. 17% MMF) and 180 d (10% MPS vs. 24% MMF, p = 0.006, log‐rank) after transplantation. There was a trend toward fewer GI‐related hospital admissions in the MPS arm (7% MPS vs. 13 …

Año de publicación:

2008

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Fuente:

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