Adverse vascular risk relates to cerebrospinal fluid biomarker evidence of axonal injury in the presence of Alzheimer’s disease pathology

Abstract:

Background: Vascular risk factors promote cerebral small vessel disease and neuropathological changes, particularly in white matter where large-caliber axons are located. How Alzheimer’s disease pathology influences the brain’s vulnerability in this regard is not well understood. Objective: Systemic vascular risk was assessed in relation to cerebrospinal fluid concentrations of neurofilament light, a biomarker of large-caliber axonal injury, evaluating for interactions by clinical and protein markers of Alzheimer’s disease. Methods: Among Alzheimer’s Disease Neuroimaging Initiative participants with normal cognition (n= 117), mild cognitive impairment (n= 190), and Alzheimer’s disease (n= 95), linear regression related vascular risk (as measured by the modified Framingham Stroke Risk Profile) to neurofilament light, adjusting for age, sex, education, and cognitive diagnosis. Interactions were assessed by cognitive …

Año de publicación:

2019

Keywords:

Fuente:

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