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Effect and safety of ribofen in rheumatoid arthritis treatment

Abstract:

Rheumatoid arthritis (RA) is a chronic inflammatory and systemic disease, that it makes evident in the articulations as synovitis, causing a progressive destruction and malformation. The purpose of this work was to evaluate the effect and safety of ribofen in rheumatoid treatment. A randomized and controlled double-blind study was carried out in patients with RA by comparing treatment with ribofen (lobenzarit disodium) and an inert placebo. Both groups of patients received 20 mg/day of piroxicam as a basal regimen during the study period of 16 weeks. The treatment carried out was the following: Group 1 (23 patients) received ribofen, 80 mg, eight hours each table (240 mg/day) and Group 2 (37 patients) received placebo, orally in both groups. A statistically significant improvement was noted in group 1 as compared to Group 2 at the end of the study. Overall clinical effectiveness was significantly higher in group 1 (78.2%) than in group 2 (35.1%). The most frecuent side effect in both groups was gastrointestinal upset, nausea, and weight loss. Our data confirm that ribofen is a useful agent in the treatment of patients with RA.