Effect of myoglobin on the muscle lipase system

Abstract:

The effect of different concentrations of myoglobin on the enzyme systems involved in lipid degradation were determined. Lipases, including both acid and neutral lipases and acid phospholipase, were inhibited by myoglobin. The neutral lipase was more susceptible to the inhibitory effect of myoglobin (35% of its initial activity at 1 mg/mL ofmyoglobin), followed closely by acid phospholipase; acid lipase activity was affected to a lesser extent (less than 20% inhibition). This inhibition was also observed on the esterase activities, being greater on the neutral esterase activity (38% of its initial activity at 1 mg/mL of myoglobin) than on the acid one. In view of these results, myoglobin could be considered as an endogenous inhibitor which would determine the lipolytic activity in different type of muscles and therefore, the rate of generation of the free fatty acids.

Año de publicación:

1996

Keywords:

Fuente:

scopus