Effect of purple corn extract on gene expression of srebp-1, Δ5d y Δ6d in mammary gland of nursing rats supplemented with chia oil (Salvia Hispánica L.)

Abstract:

The effect of the dietary intake of purple-corn extract (EMM) as a source of anthocyanins and the oral supplementation of chia oil (CH), rich in a-linolenic acid on the lipid metabolism of the mammary glands were evaluated by gene expression SREBP-1, Δ6D Δ5D in 36 nursing rats distributed in olive oil (OL), chia oil (CH), olive oil - EMM (EMM OL +) or chia oil - EMM (CH + EMM) treatments. Gene expression of SREBP-1 was similar in OL and CH, increasing in presence of EMM; suggesting that under this conditions, CH and OL oils have similar effect on SREBP-1, while anthocyanins upregulate the gene expression. ALA inhibited the expression of desaturases, and the anthocyanins imaaproved Δ5D expression at control levels similar or higher in the case of Δ6D.

Año de publicación:

2016

Keywords:

• ANTHOCYANINS
• Binding protein sterol regulatory element-1 (SREBP-1)
• Delta 5 and delta 6 desaturase
• alpha-linolenic acid
• Mammary gland

Fuente:

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scopus