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Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction

Abstract:

Abstract. The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre‐with post‐observation height in periods of 6 months with and without TRT alternated. A significant (P <0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L‐thyroxine (n= 43) during all follow‐up (97 months) showed an important recovery in height (SDS‐H = 1.67 ± 0.93 vs. 1.08 ± 0.74) which when compared with the untreated group (n= 8; 114 months; SDS‐H = ‐1.50 ± 0.83 vs. ‐1.93 ± 0.33) was significant (P < 0.001). Copyright © 1995, Wiley Blackwell. All rights reserved