Effectiveness of adaptive designs for phase II cancer trials

Abstract:

BACKGROUND: Evaluation of new therapies for cancer has suffered a paradigm shift in the last years. The use of innovative and more efficient designs is a priority for the scientific community; nevertheless, the use of this kind of design is not yet wide spread. PURPOSE: In this paper will examine the effectiveness of adaptive designs compared with traditional designs in phase II clinical trials. METHODS: We reviewed a group of abstracts records between 1980 and 2008 and extracted data regarding statistical design, year of publication, kind of evaluated product, localization, sample size and results of the trials. RESULTS: Nine hundred and eighty-nine clinical trials were identified and from them 333 traditional designs and 19 adaptive designs were included in the review. Two hundred statistical papers were located and 16 were included in the review. The most frequent designs were Standard up and down designs …

Año de publicación:

2012

Keywords:

Fuente:

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