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Effectiveness of aloe vera in patients with type 2 Diabetes Mellitus and pre-diabetes: An overview of systematic reviews

Abstract:

Background and aims: The effects of aloe vera are inconsistent and unclear. The aim of this study is to analyze the effects of aloe vera in metabolic profiles. Methods: An electronic search of systematic reviews (SRs) was performed in seven databases up to June 2021. Results: Four SRs met the eligibility criteria. In T2DM, SMD for FBG = −5.61 (p < 0.001). For HbA1c, MD = −0.95 (p = 0.02). In pre-diabetes, SMD for FBG = −1.41 (p = 0.02). For HbA1c, MD = −0.31 (p = 0.02). For TG, MD = −4.99 (p = 0.000). Conclusion: There exist a moderate to high quality of evidence in favor of the effects of aloe vera in patients with T2DM and pre-diabetes.