Effects of anaesthesia and surgery on the solubility of volatile anaesthetics in blood

Abstract:

To determine the effects of anaesthesia and surgery on the solubility of volatile anaesthetics in blood, we measured the blood/gas partition coefficients of enflurane, halothane, isoflurane, and methoxyflurane in vitro in blood obtained from six healthy unpremedicated adults at three different times during isoflurane anaesthesia: (1) awake; (2) 20 minutes after induction of anaesthesia, but before surgical incision; and, (3) 90 minutes after surgical incision. The blood/gas partition coefficients of the four volatile anaesthetics decreased significantly after induction of anaesthesia and after surgical incision (p < 0.05). Values for haematocrit and the serum concentrations of albumin, globulin, and cholesterol decreased parallel to the decrease in blood/gas partition coefficients. © 1987 Canadian Anesthesiologists.

Año de publicación:

1987

Keywords:

Fuente:

scopus