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Effects of estradiol-drosperinone or estradiol-trimegestone over lipids and lipoproteins in postmenopausal women

Abstract:

Objective: To compare the effects of estradiol-drospirenone and estradiol-trimegestone on lipids and lipoproteins in postmenopausal women. Materials and methods: Sixty-six patients who were treated with estradiol-drospirenone (group A) or estradiol-trimegestone (group B) as hormone replacement therapy for 6 months were selected. Serum cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and lipoprotein(a) concentrations were measured. Results: Cholesterol concentrations were significantly reduced after 6 months of treatment (p<0.05). In patients treated with estradiol-drospirenone, triglyceride concentrations were slightly increased after treatment, while patients treated with estradiol-trimegestone showed a mild decrease in serum concentrations after 6 months of treatment (p<0.05). Patients treated with estradiol-drospirenone showed a mild, non-significant increase in lipoprotein (a) concentrations after treatment (p=NS). Conclusion: Administration of estradiol-trimegestone produced beneficial modifications in lipid profile when compared with those produced by estradiol-drospirenone after 6 months of treatment. © 2009 Elsevier España, S.L.