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Effects of geohelminth infection and age on the associations between allergen‐specific IgE, skin test reactivity and wheeze: a case‐control study

Abstract:

Background Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age. Objective To explore the effects of geohelminth infections and age on atopy, wheeze, and the association between atopy and wheeze. Methods A case‐control study was done in 376 subjects (149 cases and 227 controls) aged 7–19 years living in rural communities in Ecuador. Wheeze cases, identified from a large cross‐sectional survey, had recent wheeze and controls were a random sample of those without wheeze. Atopy was measured by the presence of allergen‐specific IgE (asIgE) and skin prick test (SPT) responses to house dust mite and cockroach. Geohelminth infections were measured in stools and anti‐Ascaris IgE in plasma. Results The fraction of recent wheeze …