Effects of simple and angular chromones on tumor cell respiration

Abstract:

A set of structurally related compounds incorporating a chromone moiety as an essential component of their structures were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R. A tentative structure-activity relationship was found for this family of substances, suggesting that a Michael addition at C-1 is involved in the mechanism that provokes the activities.

Año de publicación:

2008

Keywords:

• Cáncer
• Cell respiration
• Chromone

Fuente:

scopus

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