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Effects of thiadiazine derivatives on the infective capacity of Leishamia amazonensis promastigotes

Abstract:

The infective capacity of Leishmania amazonensis promastigotes was evaluated after they were treated with a series of 10 thiadiazine derivatives. The parasites were incubated for 24 hours with 1 or 0,1 mg/ml of each compound and then, peritoneal macrophages from BALB/c mice were infected in cultures. All the compounds managed to reduce the infective capacity of parasites by more than 50 %. T10 product exhibited the highest effect since it reduced infection by 92,8 %.