Efficient and stereoselective synthesis of precursors for epoxypolyene cyclizations via allylic substitutions

Abstract:

A catalytic and highly stereoselective approach to precursors for epoxypolyene cyclizations based on copper-catalyzed allylic substitutions is described. The method allows introduction of various aromatic, benzyl, and alkyl groups without affecting epoxides. The compounds obtained are valuable starting materials for the synthesis of natural products and biologically active substances. © Georg Thieme Verlag Stuttgart.

Año de publicación:

2005

Keywords:

• Grignard Reagent
• Epoxides
• Cuprates
• Epoxypolyene cyclization
• Catalysis

Fuente:

scopus