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Allelic status of chromosome 1 in neoplasms of the nervous system

Abstract:

By using five highly polymorphic markers, the allelic status of chromosome 1 was established in a series of 236 tumors of the nervous system, including all major histologic subtypes: gliomas, meningiomas, neurinomas, neuroblastomas, medulloblastomas, etc. Loss of alleles at 1p was observed at significant frequencies in neuroblastomas (26% of cases), meningiomas (32%), and malignant gliomas (37%) (primarily oligodendrogliomas [94%]). This anomaly was also detected in two of 23 neurinomas, two of three neurofibrosarcomas, one primary lymphoma, and two metastatic tumors of the brain. The analysis of tumors displaying partial 1p deletions suggests the existence of two distinct regions, 1p36 and 1p35-p32, in which loci nonrandomly involved in the development of neurogenic neoplasms might be located. © 1995.

Año de publicación:

1995

Keywords:

    Fuente:

    googlegoogle
    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Cáncer
    • Patología

    Áreas temáticas:

    • Enfermedades
    • Anatomía humana, citología, histología

    Contribuidores:

    Queizan A.Queizan A.
    Pestana A.Pestana A.
    Rey J.A.Rey J.A.
    Nebreda P.Nebreda P.
    Paola E. LeonePaola E. Leone
    García-Miguel P.García-Miguel P.
    Cusak M.E.Cusak M.E.
    de Campos J.M.de Campos J.M.
    Bello M.J.Bello M.J.
    Hernández-Moneo J.L.Hernández-Moneo J.L.
    Sarasa J.L.Sarasa J.L.
    Vaquero J.Vaquero J.