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Alternative multidrug regimen provides improved suppression of HIV-1 replication over triple therapy

Abstract:

Objective: To compare the viral suppression of two antiretroviral regimens using three drugs or five drugs. Design: Two open-label studies using a three-drug (zidovudine, lamivudine and ritonavir) and a five-drug regimen (zidovudine, lamivudine, abacavir, indinavir and nevirapine) in study-drug-naive patients, except for one in the five-drug study. Methods: Participants with≥ 10 000 HIV-1 RNA copies/ml in plasma at baseline were compared by means of Kaplan-Meier curves for time to< 50 copies/ml, as well as linear regression analysis for the first phase of decline using log-transformed copy numbers. Results: The elimination rate constants for HIV-1 RNA in 15 participants of the three-drug study were compared with nine participants of the five-drug study. The level of< 50 copies/ml was reached earlier when using the five-drug than when using the three-drug regimen (P log rank= 0.0005): median time to reach this …