Alzheimer’s disease in Latin America and Caribe

Abstract:

Alzheimer’s disease is the most common dementia in elder people, where Apolipoprotein E ε4 genotype is the most clearly documented and studied risk factor. Today, over 46 million people live with dementia worldwide and 46% of it lives in Latin America making it a global health and social care challenge. In this review, we aimed to gather all the studies done in Alzheirmer’s disease and ApoE in Latin America in order to acknowledge the level of research, allele frequency along the continent and ethnic groups, level of awareness, status and cost of this disorder represents. The search yielded around 50 publications performed in differents parts of Central and South America and Caribe. However, in several countries no data were found, meaning whether the search was no so inclusive or research in that field is still missing. ApoE Odds ratios varied along the continent, finding the highest in Brazil and Cuba. In most of the populations and ethnic groups ApoE allele frecuencies followed the same pattern ε3> ε4> ε2 and the variation of these are thought to be result of admixture, genetic drift and natural selection. Latin America is and will face dementia

Año de publicación:

2016

Keywords:

Fuente:

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