Regresar

Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release

Abstract:

It has been reported that DIC can react with OxymaPure to render an oxadiazole compound with the concomitant formation of HCN. Here we demonstrate that this reaction is not a feature of all carbodiimides but rather depends on the alkyl structure that flanks the two N atoms of the carbodiimide. Furthermore, we have identified two carbodiimides, TBEC and EDC·HCl, whose reaction with OxymaPure is exempt from HCN formation.

Año de publicación:

2021

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Química orgánica
    • Ingeniería química

    Áreas temáticas:

    • Química analítica
    • Farmacología y terapéutica

    Contribuidores:

    Luna O.Luna O.
    El-Faham A.El-Faham A.
    Alberício F.Alberício F.
    Manne S.R.Manne S.R.
    B. G. De la TorreB. G. De la Torre
    Royo M.Royo M.
    Acosta G.A.Acosta G.A.
    Orosz G.Orosz G.