Amide-to-ester substitution in coiled coils: The effect of removing hydrogen bonds on protein structure

Abstract:

(Figure Presented) The latest twist: The effect of backbone H-bonding on the stability of proteins was studied by experimental techniques and molecular dynamics simulation. The structure of the coiled-coil model peptide examined (see picture) is affected by interactions in the solvent-exposed regions as well as by interhelical hydrophobic interactions. © 2007 Wiley-VCH Verlag GmbH &. Co. KGaA.

Año de publicación:

2007

Keywords:

• Superhelices
• Depsipeptides
• Hydrogen bonds
• Protein folding
• molecular dynamics

Fuente:

scopus

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