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Essential oils, herbal extracts and propolis for alleviating Helicobacter pylori infections: A critical view

Abstract:

Helicobacter pylori is classified as Class I human carcinogen, is known for gastric, peptic duodenal ulcers and other gastrointestinal tract disorders. The treatment against H. pylori involving triple therapy with the use of a proton pump inhibitor and the combination of two different antibiotics. This approach has not been successful, but has led to some emerging therapies (e.g. second eradication, quadruple, sequential), which are also not very effective against H. pylori as this bacterium has multidrug resistance. This situation warrants discovering alternative therapeutic strategies against H. pylori by using natural products with low or no side effects. This review summarizes the antimicrobial activity of essential oils (EOs) of different aromatic plants against H. pylori related infections. More than twenty EOs and herbal extracts have been identified as potential natural products against H. pylori. Chemical constituents of these EOs and herbal extracts were found to be tannins, terpenoids, glycosides, phenolic compounds, flavonoids, alkaloids, saponins, amino acids, reducing sugars, and proteins.