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An update of STR mutation rates from paternity tests analyzed in a 14 year period (2005–2018) at IdentiGEN lab, Universidad de Antioquia, Colombia

Abstract:

DNA testing is the gold standard for biological filiation and human identification, based mainly on a large number of polymorphisms of STRs, which are caused mostly by relatively frequent mutations. Changes in the size of alleles in the STR sequences are frequently associated with these mutations, causing alterations in the statistical calculations of tests, thereby lowering the paternity index (PI). To avoid such alterations and obtain a paternity probability (W) above 99.99%, it is necessary to increase the number of STRs analyzed and to know the appearance frequency of these mutations. In the present study, 17 STR were analyzed in a total of 11,077 cases, according to the paternity reports issued by the IdentiGEN Lab, focused mainly on the population of Antioquia, during 14 years (2005–2018). A total of 251 mutations were found in all the cases studied; of these, 247 were one-step mutations, 3 were two-step and only one three-step mutation was observed.