1481P Expression of ERBB2 and PD1 mRNA in advanced gastric cancer

Abstract:

Background Quantitative measurements of ERBB2 and PD1 mRNA in gastric cancer (GC) could better reflect the status of HER2 and the amount of immune infiltration than standard pathology-based methods. Methods A retrospective cohort of patients (pts) with advanced GC treated at Hospital Clinic of Barcelona was evaluated. HER2 status was identified by immunohistochemistry (IHC) and/or in situ hybridization (ISH) according to guidelines. ERBB2 and PD1 mRNA levels were measured from archival formalin-fixed paraffin-embedded tumors using the nCounter platform. To compare ERBB2 levels, we evaluated an in-house cohort of 392 breast cancers (BC). Cox models and logistic regressions were used to associate ERBB2 or PD1 expression with progression free survival (PFS) and response following a trastuzumab-based chemotherapy (T-chemo). Descriptive statistics were also used. Results 75 pts were …

Año de publicación:

2020

Keywords:

Fuente:

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