162 Methionine Supply during Late-Gestation Triggers Sex-Specific Divergent Trajectories of Metabolism and Epigenetic Systems in Bovine Placenta.

Abstract:

In non-ruminant species, males and females respond differently to gestational nutrition, and placenta, as a widely recognized programming agent, contributes to the underlying processes. According to our previous findings, methionine (a methyl donor) supply during late pregnancy increases calves’ body weight at birth, at least in part through upregulation of nutrient transporters. However, the effects of methionine on placenta metabolism and epigenetic signatures are not clear. Thus, we further investigated the impact of methionine supply during late gestation and the calf’s sex on metabolism and DNA methylation in bovine placenta. Multiparous cows were fed during the last 28 days of pregnancy with a control (CTR) or methionine-supplemented (MET; Mepron®, Evonik Nutrition & Care GmbH, Germany) diet. Mepron was supplied at a rate of 0.09% of the dry matter of the diet to ensure a ratio of Lysine to …

Año de publicación:

2018

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Fuente:

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