172 pg mg-1 2h-1) and the non-pregnant control group (237+ 146 pg mg-1 2h-1) showed similar PGI2

Abstract:

Pregnancy-induced hypertension (PIH) continues to be a common cause of maternal-fetal morbidity and mortality (1). However, the precise factors involved in the etiopathology of PIH are still unknown (2, 3). Recent theories on the etiology of PIH emphasize a role of PGI2 production in the feto-placental unit (4, 5). While there is general agreement that PGI2 production in the umbilical artery is reduced in PIH, little information is available about whether this is also true for maternal vascular tissues (6). Thus, the objective of the present study was to investigate the production of PGI2 by vascular maternal-fetal tissues in Equadorian Andean women. This population shows certain maternal risk factors such as young maternal age, nulliparity, residence at high altitudes, low dietary calcium intake and consequently shows a high incidence of PIH (7-10). The study was approved by the Ethical Committee of the Medical School and was conducted at the “Hospital Gineco-Obstétrico Isidro Ayora"(HGOIA), Quito, Ecuador. Pregnant women were selected according to the following criteria: nulliparity, age< 25 years, residence in Quito (2800 m altitude), delivery by caesarean section. Pregnancy was defined as normal when: 1) there were no pre-existing or pregnancy-induced complications,

Año de publicación:

1991

Keywords:

Fuente:

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