2-Cyano-6-(trifluoromethyl)-4H-pyran-4-one: A novel versatile CF <inf>3</inf>-containing building block

Abstract:

A highly electrophilic pyrone, 2-cyano-6-(trifluoromethyl)-4H-pyran-4-one, was synthesized. The reactions of this cyanopyrone with N-nucleophiles can proceed with or without substitution of the cyano group to give a wide range of novel trifluoromethylated compounds. An oxindole derivative was synthesized from a phenylhydrazide using unusual (acidic) conditions. © 2012 Elsevier B.V.

Año de publicación:

2012

Keywords:

• Carbamoylated aminoenones
• 2-Cyano-6-(trifluoromethyl)-4H-pyran-4-one
• Oxindole
• Rotamers
• Trifluoromethylated 2-pyridones

Fuente:

scopus