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2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis

Abstract:

2-MeTHF and CPME were evaluated as greener alternatives for the most employed solvents in peptide synthesis. The ability of these solvents to dissolve amino acid derivatives and a range of coupling reagents were evaluated as well as the swelling of polystyrene and polyethylene glycol resins. In addition, racemization and coupling efficiencies were also determined. We concluded that the use of 2-MeTHF with combination of DIC/OxymaPure gave the lowest racemization level during stepwise synthesis of Z-Phg-Pro-NH2 and the highest purity during SPPS of Aib-enkephalin pentapeptide (H-Tyr-Aib-Aib-Phe-Leu-NH2).

Año de publicación:

2016

Keywords:

  • Solid-phase peptide synthesis
  • Cyclopentyl methyl ether
  • Green solvents
  • 2-methyltetrahydrofuran
  • Peptide synthesis

Fuente:

scopusscopus

Tipo de documento:

Article

Estado:

Acceso restringido

Áreas de conocimiento:

  • Bioquímica
  • Ingeniería química
  • Bioquímica

Áreas temáticas:

  • Química orgánica

Contribuidores:

Govender T.Govender T.
El-Faham A.El-Faham A.
Alberício F.Alberício F.
Kruger H.G.Kruger H.G.
B. G. De la TorreB. G. De la Torre
Khattab S.N.Khattab S.N.
Jad Y.E.Jad Y.E.
Acosta G.A.Acosta G.A.