Ether à go-go potassium channels and cancer

Abstract:

Ion channels play important roles in health and disease. In the last few years, an interesting relationship between potassium channels and cancer has evolved. Especially, members of the ether à go-go (EAG) potassium channels family have gained interest as research tools for detection and therapy of different cancers. This review will summarize most of the findings relating EAG channels and cancer, focusing on mRNA expression in tissues, oncogenic properties, modulation and pharmacology. Plausible scenarios on the cellular mechanisms of EAG oncogenicity will be discussed. © 2005 Elsevier Ireland Ltd. All rights reserved.

Año de publicación:

2006

Keywords:

• ion channels
• Patch-clamp
• human papilloma virus
• Von hippel-lindau protein
• Hypoxia
• Herg
• Proliferation
• Tamoxifen
• tumor markers
• Epsin
• Ether à go-go
• Potassium channels
• Cáncer
• Cervical Cancer

Fuente:

scopus