Analysis of insulin and cytokines during development using a multiplexed immunoassay: implications in pediatrics

Abstract:

Results The concentrations of insulin, resistin and leptin increased during development, with higher levels found in females. Adiponectin levels did not change, although higher concentrations were also observed in females than in males. Interleukin-6 and 8 increased and interleukin-1β levels decreased throughout development, without any evidence of sexual dimorphism. There are good correlations between adiponectin and sex-hormone binding globulin, as well as between leptin and Δ4-androstenedione. Conclusions Changes in these parameters seem to be related with adrenal and gonadal function. Pubertal stage and sex must be taken into consideration when these data are used.

Año de publicación:

2011

Keywords:

Fuente:

google