Analysis of the distribution of HLA-A alleles in populations from five continents

Abstract:

The variation and frequency of HLA-A genotypes were established by PCR-SSOP typing in diverse geographically distributed populations: Brazilian, Colombian Kogui, Cuban, Mexican, Omani, Singapore Chinese, and South African Zulu. HLA-A allelic families with only one allele were identified for HLA-A∗01, -A∗23, -A∗25, -A∗31, -A∗32, -A∗36, -A∗43, -A∗69, -A∗80; and with two alleles for HLA-A∗03, -A∗11, -A∗26, -A∗29, -A∗33, -A∗34, and -A∗66. Greater variation was detected for HLA-A∗02, -A∗24, and -A∗68 allele families. Colombian Kogui and Mexican Seris showed the least diversity with respect to HLA-A alleles, albeit with small numbers tested, with only four and five HLA-A alleles identified, respectively. It would appear by their presence in all populations studied, either rural or indigenous, that certain alleles are very important in pathogen peptide presentation.

Año de publicación:

2000

Keywords:

Fuente:

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