Evaluation of a vancomycin dosing regimen for patients on high flux hemodialysis: an observational study.

Abstract:

Results Twenty-one patients met the inclusion criteria. All of them were treated with 1 gm LD of vancomycin and 500 mg MD protocol. The mean pre-dialysis concentration# 1 was 10.8 ug/mL. The mean pre-dialysis concentration# 2 was 13 ug/mL, and the mean pre-dialysis concentration# 3 was 12 ug/mL. Only 36% of HFHD sessions achieved an adequate vancomycin level. A liner regression analysis pbkp_redicted that a loading dose of 23 mg/kg LD and 8 mg/kg MD achieved the recommended pre-dialysis vancomycin concentration. Conclusions Current dose regimen of 1 gm LD and 500 mg MD of Vancomycin are not adequate to achieve recommended pre-dialysis level of 15-20 ug/mL for health care associated infections, bacteremia and osteomyelitis in most patients on HFHD. Based on our statistical analysis, we recommended that 23 mg/kg of LD and 8 mg/kg of MD would achieve an adequate vancomycin level.

Año de publicación:

2012

Keywords:

Fuente:

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