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Evidence that natural cytotoxicity and antibody-dependent cellular cytotoxicity are mediated in humans by the same effector cell populations

Abstract:

The present study strongly suggests that, in humans, natural killer (NK) activity and antibody-dependent cell-mediated cytotoxicity (ADCC) are mediated by the same effector cell population. This is supported by two different experimental approaches. First, competition for NK effector cells was accompanied by simultaneous inhibition of ADCC activity. Target cells sensitive to NK activity were capable of inhibiting specifically an ADCC assay in cold target competition experiments. Second, specific removal of NK cells on monolayers formed by target cells sensitive to NK activity caused simultaneous depletion of ADCC effector cells. In association with the removal on the monolayers of effector cells for ADCC as well as NK activity, we also found a significant depletion of cells bearing Fcγ receptors.

Año de publicación:

1979

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Inmunología
    • Inmunología

    Áreas temáticas:

    • Fisiología humana

    Contribuidores:

    ALVAREZ J.M.ALVAREZ J.M.
    SILVA A.G.SILVA A.G.
    Manuel Ortiz de LandázuriManuel Ortiz de Landázuri
    Herberman R.B.Herberman R.B.