Evidence-based effects of multicomponent exercise training on biomarkers related to frailty in older persons: a systematic review

Abstract:

Introduction: Frailty is a complex syndrome that can is characterized by the loss of physical functional capacity. The effects of multicomponent exercise training on frailty and correlated biomarkers are not yet fully explored in the scientific literature. Objective: Based on the available literature data, our first endpoint in this systematic review was to present the current knowledge on the influence of multicomponent exercise training in older persons diagnosed with the frailty syndrome. In addition, a second endpoint was to identify not only the most evaluated and responsive biochemical markers in this population, but also how they responded to multicomponent exercise training. Methods: The electronic databases PubMed, SciELO, LILACS, and Science Direct, were accessed. The search was conducted in the English language using MeSH keywords in order to verify which biochemical markers were investigated in the studies that associated frail older persons and multicomponent physical exercise. This systematic review was registered under the reference CRD42018089912. Results: Six randomized controlled trial studies met our inclusion criteria and were used to perform this review. In response to our endpoints, these studies reported that multicomponent exercise training was able to decrease or reverse frailty by improving functional fitness, muscle strength, speed and agility. In addition, this type of exercise training was associated with alteration in several biomarkers, namely C-reactive protein (CRP), interleukin (IL-6), Tumour Necrosis Factor (TNF-α), insulin-like growth factor (IGF-1), haemoglobin (HbA), albumin, oxidation products, antioxidants …

Año de publicación:

2021

Keywords:

Fuente:

google