Regresar

Exploiting the Thiobarbituric Acid Scaffold for Antibacterial Activity

Abstract:

Thiobarbituric acid (TBA) has been considered a privileged structure for developing antimicrobial agents. Diversity was obtained at positions N and at C5 through acylation, Schiff base formation, Knoevenagel condensation, and thioamide and enamine formation. The present work describes the synthesis of small libraries based on the TBA moiety and above-mentioned reactions. Preliminary antimicrobial activity screening of the prepared compounds against selected bacteria (both Gram-positive and -negative) showed the best results for the Boc-Phe-TBA derivative. These results could be useful for designing and building libraries based on other amino acids with distinct protecting groups.

Año de publicación:

2018

Keywords:

  • Thiobarbituric acid
  • nanoformulations
  • Antibiotics
  • barbituric acid

Fuente:

scopusscopus

Tipo de documento:

Article

Estado:

Acceso restringido

Áreas de conocimiento:

  • Descubrimiento de fármacos
  • Resistencia antimicrobiana
  • Farmacología

Áreas temáticas:

  • Farmacología y terapéutica
  • Química orgánica

Contribuidores:

Almarhoon Z.M.Almarhoon Z.M.
Zamisa S.J.Zamisa S.J.
El-Faham A.El-Faham A.
Alberício F.Alberício F.
Sharma A.Sharma A.
B. G. De la TorreB. G. De la Torre
Hazzah H.A.Hazzah H.A.
Noki S.Noki S.