FRI0429 Hypocomplementaemia in A Cohort of Patients with Primary Sjogren's Syndrome (Gessar Registry)

Abstract:

Background the clinical significance of hypocomplementaemia in primary Söjgren Syndrome (SSp) is being studied due to recent studies that associated low complement levels with lymphoma development and mortality. Objectives 1-To determine whether patients with SSp and hypocomplementaemia (C3 and/or C4) at diagnosis have an increased frequency of clinical manifestations (at least one of the following: parotid swelling, arthritis, Raynaud, purple, lung parenchymal involvement, renal impairment, neuropathy and lymphoma) compared with patients with normal complement. 2 - Assess differences between groups having each particular clinical manifestations, laboratory abnormalities and treatment with corticosteroids and immunosuppressants. Methods We evaluated patients diagnosed SSp (all fulfilled the 2002 European American Criteria), using the GESSAR database of those patients with complement …

Año de publicación:

2014

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Fuente:

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