Animal model of renal AL-amyloidogenesis recapitulates in vitro findings

Abstract:

In vitro studies dealing with amyloid formation by mesangial cells have been reported in the literature in the last decade. Crucial steps in the cascade of events that result in the formation of amyloid fibrils have been elucidated in the laboratory using in vitro models. However, the findings have not been reproduced in vivo, creating some doubts as to the significance and clinical application of the information that has been elucidated. In the work described in this extended abstract, it is shown that the in vivo model recapitulates the findings in the in vitro models. This is a significant scientific advance towards future development of new therapeutic avenues to address the progressive renal failure that currently characterizes renal AL-amyloidosis. The information that has been gathered regarding the pathogenesis of amyloidosis in vitro and in vivo is in the process of being translated to the clinical arena where …

Año de publicación:

2011

Keywords:

Fuente:

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