3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity

Abstract:

Previously, chemistry effort on the gem-cyclohexane series of γ-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high γ-secretase activity.

Año de publicación:

2006

Keywords:

Fuente:

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