327 Loss of weight and mortality in heart failure

Abstract:

Background: Chronic kidney disease (CKD),[estimated glomerular filtration rate (eGFR)< 60ml/min/1.73 m2], present in about 1/3 of ambulatory patients with heart failure (HF) and reduced ejection fraction (EF), is an independent pbkp_redictor of the risk of fatal and non-fatal cardiovascular (CV) events. The Prevalence of CKD and whether it is an independent pbkp_redictor of CV outcomes has not been defined in patients with HF and preserved EF (HF-PEF). Methods: The Irbesartan in Heart Failure with Preserved Systolic Function Trial (I-PRESERVE) randomized 4128 patients with an EF≥ 45% to receive irbesartan or placebo; eGFR was calculated in 4052 using the simplified Modification of Diet in Renal Disease (MDRD) formula. The primary outcome of all-cause mortality or CV hospitalization (myocardial infarction, stroke, worsening HF, arrhythmia or unstable angina) over one year of follow-up was compared between …

Año de publicación:

2008

Keywords:

Fuente:

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