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359 Myostatin serum levels in heart failure

Abstract:

Background: muscle wasting is quite frequent in heart failure (HF). However, the mechanisms involved in this process and its clinical and prognostic implications are fare to be elucidated. In recent years, myostatin (MYOS) has became as an important modulator of muscle catabolism. Objective: to assess the MYOS and MYOS pro-peptide precursor (pro-MYOS) serum levels determined by commercial ELISA in patients with HF, and to analyse the possible relationship of such peptides with age, sex, several currently used parameters of HF severity, metabolic parameters, and also with the prognosis. In addition the possible correlation of these peptides with TNF-alfa soluble receptor 2 (TNFR2) and with NT-proBNP serum levels was also evaluated. Patients: 70 patients (70% men, median age 72.3 years [34.9-82.7]), who where in NYHA functional class I (15), II (15), III (35) and IV (5) were included in the study. Median LVEF was 32%(range 8-72%). Etiology of HF was mainly ischemic heart disease (66%), followed by dilated cardiomyopathy (10%). Mean follow-up was 538±40 days. Results: 13 patients (18.6%) died during follow-up. Mean value of MYOS was 12.3±7.2 ng/ml. Median value of pro-MYOS was 0.1 ng/ml (range 0.1-15). Median value of TNFR2 was 2.42 ng/ml (range 0.08-25.75). Median value of NT-proBNP was 899.5 pg/ml (range 57-25398). No significant correlation was found between MYOS and pro-MYOS. We did not found any relationship between MYOS or pro-MYOS and NYHA functional class groups. In contrast, both NT-proBNP (p< 0.001) and TNFR2 (p= 0.001) were significantly related to NYHA functional class. No correlation …