Anti-metastic and anti-proliferative activity of ilex guayusa, uncaria tomentosa and croton lechleri, in the mcf7 cell line.

Abstract:

Breast cancer is the second leading cause of death in women worldwide, among the most common neoplasms in the female sex followed by cervical, thyroid, stomach and colorectal cancer; breast cancer is the neo-plasm that has the greatest impact in Ecuadorian women. In this context, Ecuador is a country with a great biodiversity in flora and ethnicities, where plants have been used over time as a treatment for various diseases. Ancestral knowledge and the use of plants in the country are transmitted empirically, hence the importance of derived research that provides a scientific suste-nance of their effects. The objective of the research was to evaluate the anti-proliferative and anti-metastatic effect of Ilex guayusa, Uncaria tomentosa and Croton lechleri extracts on the MCF-7 breast cancer cell line. The results showed that several of the extracts analyzed possessed an anti-proliferative activity on MCF-7, with Croton lechleri extract having the greatest effect in inhibiting cell proliferation. Furthermore, the Soft Agar trial, made it possible to determine that the extracts of Ilex guayusa had an anti-metastasic activity dependent on concentration.

Año de publicación:

2021

Keywords:

• Anti-metastic
• Uncaria tomentosa
• Mama cancer
• CROTON LECHLERI
• Anti-proliferative
• Ilex guayusa
• MCF-7

Fuente:

scopus