Antibiotic treatment is associated with reduced risk of a subsequent exacerbation in obstructive lung disease: an historical population based cohort study

Abstract:

Objectives: The risk of a subsequent exacerbation after treatment of an exacerbation with oral corticosteroids without (OS) or with (OSA) antibiotics was evaluated in a historical population based cohort study comprising patients using maintenance medication for obstructive lung disease. Methods: The Pharmo database includes drug dispensing records of more than 2 million subjects in The Netherlands. Eligible were patients ⩾50 years who in 2003 were dispensed ⩾2 prescriptions of daily used inhaled β2 agonists, anticholinergics and/or corticosteroids, and experienced at least one exacerbation before 1 January 2006. Exacerbation was defined as a prescription of OS or OSA. The times to the second and third exacerbations were compared using Kaplan–Meier survival analysis. Independent determinants of new exacerbations were identified using multivariable Cox recurrent event survival analysis. Results: Of 49 …

Año de publicación:

2008

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Fuente:

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